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Publications

Journal Cover of Past Publications of Sun Lab on Immune and Gene Engineering at Mount Sinai

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  1. Xiaoqi Sun#, Xingwu Zhou, Xiaoyue Shi, Omar Abed, Xinran An, James J. Moon#. “Metalloimmunotherapy: A paradigm shift of metallodrugs.” Nature Biomedical Engineering. 10.1038/s41551-024-01221-7 (2024). (# co-corresponding author)

  2. Xiaoqi Sun1, Xuehui Huang1, Kyung Soo Park1, Xingwu Zhou, Andrew Kennedy, Carla D. Pretto, Qi Wu, Ziye Wan, Yao Xu, Wang Gong, Jonathan Z. Sexton, Andrew Tai, Yu Leo Lei, James J. Moon. “Novel STING-activating Nanoparticle for Effective Cancer Immunotherapy and Vaccine Applications.” ACS Nano. 10.1021/acsnano.3c11374 (2024).

  3. Marisa E. Aikins1, Xiaoqi Sun1, Hannah Dobson, Xingwu Zhou, Yao Xu, Yu Leo Lei, James J. Moon#. “STING-activating Cyclic Dinucleotide-Manganese Nanoparticles Evoke Robust Immunity against Acute Myeloid Leukemia.” Journal of Controlled Release. 368:768-779 (2024).  (1Co-first author).

  4. Xiaoqi Sun#, Xingwu Zhou, Yu L. Lei, James J. Moon#. “Unlock the promise of systemic STING agonist immunotherapy” Journal of Controlled Release. 357, 84-93 (2023) (# co-corresponding author)

  5. Alexander G. Allen, Samia Q. Khan, Carrie M. Margulies, Ramya Viswanathan, Swarali Lele, Sean N. Scott, Laura Blaha, Rithu Pattali, Kaitlyn M. Izzo, Alexandra Gerew, Nadire R. Cochran, Carl S. Holland, Meng Wu, Aaron C. Wilson, Xiaoqi Sun, Patrizia Mazzucato, Georgia Giannoukos, Eugenio Marco, Michael Nehil, Kai-Hsin Chang, John A. Follit, Kate Zhang, Mark S. Shearman, Christopher J. Wilson, John A. Zuris. “SLEEK: A method for highly efficient knock-in and expression of transgene cargos for next-generation cell-based medicines”. Nature Biotechnology. 10.1038/s41587-023-01779-8 (2023) ---- reported the most effective gene editing technology to knock in transgene cargos for cell therapy.

  6. Cheng Xu, Hannah E Dobson, Mengjie Yu, Wang Gong, Xiaoqi Sun, Kyung Soo Park, Andrew Kennedy, Xingwu Zhou, Jin Xu, Yao Xu, Andrew W Tai, Yu Leo Lei, James J Moon. “STING agonist-loaded mesoporous manganese-silica nanoparticles for vaccine applications” Journal of Controlled Release. 357, 84-93 (2023)

  7. Xiaoqi Sun, Yu Zhang, Jiaqian Li, Kyung Soo Park, Kai Han, Yao Xu, Jutaek Nam, Jin Xu, Yu L. Lei, James J. Moon. “Amplifying STING Activation by Cyclic Dinucleotide-Manganese Particles for Local and Systemic Cancer Metalloimmunotherapy.” Nature Nanotechnology. 16, 1260–1270 (2021) ---- result in a VC-backed startup company Saros Therapeutic for clinical translation.

  8. Kyung Soo Park1, Xiaoqi Sun1, Marisa Aikins1, James J. Moon. “Non-viral COVID-19 vaccine delivery systems.” Advanced Drug Delivery Reviews. 169, 137-151 (2021) (Co-first author)

  9. Kai Han, Jutaek Nam, Jin Xu, Xiaoqi Sun, Xuehui Huang, Olamide Animasahun, Abhinav Achreja, Jin Heon Jeon, Benjamin Pursley, Nobuhiko Kamada, Grace Y Chen, Deepak Nagrath, James J Moon. Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel. Nature Biomedical Engineering. 5, 1377–1388 (2021)

  10. Rui Kuai1, Priti Singh1, Xiaoqi Sun1, Cheng Xu, Alireza Hassani Najafabadi, Lindsay Scheetz, Wenmin Yuan, Yao Xu, Renu Jain, Anna Schwendeman, James J. Moon. “Efficient infiltration of CD8+ T cells in multiple murine tumors following nanodiscs cancer vaccine.” Advanced Therapeutics 3 (9), 2000094 (2020). (Co-first author)

  11. Lindsay Scheetz1, Padma Kadiyala1, Xiaoqi Sun1, Alireza Hassani, Marisa Aikins, Pedro R. Lowenstein, Maria G. Castro, Anna Schwendeman, and James J. Moon. “Synthetic high-density lipoprotein nanodiscs for personalized vaccination against glioblastoma multiforme.” Clinical Cancer Research 10.1158/1078-0432.CCR-20-0341 (2020). (Co-first author).

  12. Yu Yang, Xiaoqi Sun, Jun Xu, Cheng Cui, Hoda Safari Yazd, Xiaoshu Pan, Yujie Zhu, Xigao Chen, Xiaowei Li, Jin Li, Weihong Tan. “Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy.” ACS nano 14 (8), 9562-9571 (2020).

  13. Kyung Soo Park, Cheng Xu, Xiaoqi Sun, Cameron Louttit, James J Moon. “Improving STING Agonist Delivery for Cancer Immunotherapy Using Biodegradable Mesoporous Silica Nanoparticles.” Advanced Therapeutics doi.org/10.1002/adtp.202000130.

  14. Rui Kuai, Xiaoqi Sun, Wenmin Yuan, Lukasz J Ochyl, Yao Xu, Alireza Hassani Najafabadi, Lindsay Scheetz, Anna Schwendeman, and James J Moon. "Dual TLR Agonist Nanodiscs as a Strong Adjuvant System for Vaccines and Immunotherapy." Journal of Controlled Release 282, 131-139 (2018).

  15. Yang, Rong, Jun Xu, Ligeng Xu, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng, and Zhuang Liu. "Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination." ACS Nano 12 (6), 5121-5129 (2018).

  16. Rui Kuai1, Xiaoqi Sun1, Wenmin Yuan, Yao Xu, Anna Schwendeman, and James J Moon. "Subcutaneous Nanodisc Vaccination with Neoantigens for Combination Cancer Immunotherapy." Bioconjugate chemistry 29 (3), 771-775 (2018). (Co-first author)

  17. Xiaoqi Sun, Xiao Han, Ligeng Xu, Min Gao, Jun Xu, Rong Yang, and Zhuang Liu. "Surface‐Engineering of Red Blood Cells as Artificial Antigen Presenting Cells Promising for Cancer Immunotherapy." Small 13 (40), 1701864 (2017). ---- reported the first red blood cell (RBC)-based artificial antigen-presenting cell (aAPC), which is adopted by Rubius Therapeutics to design RTX-321.

  18. Chen, Qian, Chao Liang, Xiaoqi Sun, Jiawen Chen, Zhijuan Yang, He Zhao, Liangzhu Feng, and Zhuang Liu. "H2O2-Responsive Liposomal Nanoprobe for Photoacoustic Inflammation Imaging and Tumor Theranostics via in Vivo Chromogenic Assay." Proceedings of the National Academy of Sciences. 114, 5343-5348 (2017).  ------ conceived the idea, did proof of concept experiments, transferred to coworkers due to change of lab.

  19. Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, Zhuang Liu. “Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses” Nature Communication. 8, 902 (2017).

  20. Gao, Min, Aiyan Hu, Xiaoqi Sun, Chao Wang, Ziliang Dong, Liangzhu Feng, and Zhuang Liu. "Photosensitizer Decorated Red Blood Cells as an Ultrasensitive Light-Responsive Drug Delivery System." ACS applied materials & interfaces. 9, 5855-5863 (2017).

  21. Guangbao Yang, Xiaoqi Sun, Jingjing Liu, Liangzhu Feng, and Zhuang Liu. "Light-Responsive, Singlet Oxygen-Triggered On-demand Drug Release from Photosensitizer-Doped Mesoporous Silica Nanorods for Cancer Combination Therapy." Advanced Functional Materials. 26, 4722-4732 (2016).

  22. Dong, Ziliang, Liangzhu Feng, Wenwen Zhu, Xiaoqi Sun, Min Gao, He Zhao, Yu Chao, and Zhuang Liu. "CaCO3 Nanoparticles as an Ultra-Sensitive Tumor pH-Responsive Nanoplatform Enabling Real-Time Drug Release Monitoring and Cancer Combination Therapy." Biomaterials. 110, 60-70 (2016).  

  23. Ziliang Dong, Hua Gong, Min Gao, Wenwen Zhu, Xiaoqi Sun, Liangzhu Feng, Tingting Fu, Yonggang Li, and Zhuang Liu. "Polydopamine Nanoparticles as a Versatile Molecular Loading Platform to Enable Imaging-Guided Cancer Combination Therapy." Theranostics. 6, 1031 (2016).

  24. Guosheng Song, Yuyan Chen, Chao Liang, Xuan Yi, Jingjing Liu, Xiaoqi Sun, Sida Shen, Kai Yang, and Zhuang Liu. "Catalase-Loaded TaOx Nanoshells as Bio-anoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy." Advanced Materials. 28, 7143-7148. (2016).  

  25. Xiaoqi Sun, Chao Wang, Min Gao, Aiyan Hu, Zhuang Liu. “Remotely Controlled Red Blood Cell Carriers for Cancer Targeting and Near-infrared Light-triggered Drug Release in Combined Photothermal-chemotherapy” Adv. Funct. Mater. 25, 2386–2394. (2015). (Back cover article)

  26. Wenwen Zhu, Kai Liu, Xiaoqi Sun, Xin Wang, Yonggang Li, Liang Cheng, and Zhuang Liu, “Mn2+-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance” ACS Appl. Mater. Interfaces, 21, 11575–11582 (2015).

  27. Yu Yang, Jingjing Liu, Xiaoqi Sun, Liangzhu Feng, Wenwen Zhu, Zhuang Liu, Meiwan Chen. “Near-infrared light-activated cancer cell targeting and drug delivery with aptamer- modified nanostructures” Nano Research, 10.1007/s12274-015-0898-4 (2015).

  28. Guangbao Yang, Hua Gong, Teng Liu, Xiaoqi Sun, Liang Cheng, Zhuang Liu. “Two- dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer” Biomaterials, 60, 62-71 (2015).  

  29. Chao Wang, Xiaoqi Sun, Liang Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu. “Multifunctional theranostic red blood cells for magnetic field enhanced in vivo combination therapy of cancer” Adv. Mater. 26, 4794-4802. (2014).

  30. Xuejiao Song, Hua Gong, Teng Liu, Liang Cheng, Chao Wang, Xiaoqi Sun, Chao Liang, Zhuang Liu. “J-aggregates of organic dye molecules complexed with iron oxide nanoparticles for imaging-guided photothermal therapy under 915-nm light” Small, 10, 4362-4370 (2014).

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